Side Effects caused by Injectable Fertility Drugs (Gonadotropins)

HMG Injections

What are gonadotropins?

Gonadotropins are fertility inducing drugs. It is administered by injection and contain follicle-stimulating hormone (FSH). The hormone FSH is either injected alone or sometimes along with luteinizing hormone (LH). During a regularly occurring menstrual cycle, the pituitary gland in the brain is responsible for stimulating FSH and LH to produce an egg in ovary. When FSH (alone or with LH) is injected, it stimulates the ovary to make multiple follicles (cysts containing eggs). There are other fertility drugs as well such as clomiphene citrate, which work in tandem with the brain in order to coax the ovaries to produce egg.

How are these medications used?

Gonadotropins are employed by doctors during fertility treatments, generally during intrauterine insemination (IUI) or in vitro fertilization (IVF). Injections of gonadotropins are given in the beginning of the menstrual cycle to encourage production of multiple healthy eggs. Human chorionic gonadotropin (hCG) is then injected to stimulate the ovary to release the egg once it reaches maturity.  During the treatment, doctors monitor the patients closely using ultrasound to prevent side effects and risks.

What are some of the potential side effects of gonadotropins?

Ovarian Hyper stimulation Syndrome (OHSS)

OHSS refers to the condition in which the ovaries become large and fluid accumulates in the abdomen. Around 10% to 20% of patients complain of discomfort but the symptoms usually go away in due course of time. However, more severe complications can occur in approximately 1% of the cases marked by nausea, vomiting, fast weight gain, dehydration, blood clots, kidney dysfunction, twisting of an ovary (torsion), fluid collections in the chest and abdomen, and, in rare conditions even death.

Using injectable gonadotropins enhances the probability of multiple implantations (twins or more), by as much as 30 % which in normal pregnancy occur in 1% to 2% of women. There is 5% chance of triplets as well.  Being pregnant with twins or triplets puts a woman at risk by enhancing the threat of miscarriage, premature delivery, abnormalities in the new born baby, pregnancy-induced hypertension, bleeding, along with other pregnancy related complications.

Sildenafil Tablet effective for treating sexual dysfunction

Sildenafil Tablet

Sildenafil available under the commercial name Viagra is a popular medicine used to treat male sexual problems primarily erectiledysfunction or impotence. ED refers to the inability of penis to achieve erection to perform normal sexual intercourse. The medicine dilutes blood vessels which increase blood flow to the penis and helps it achieve erection.

Please note that this drug is specifically used for helping a person achieve erection. It offers no protection against sexually transmitted diseases such as syphilis, HIV, Hepatitis B and gonorrhea among others.

How to use this medicine?

This drug is taken orally and in dosage prescribed by the doctor. In order to achieve satisfactory sexual performance, it is recommended to take the drug 30 minutes before sexual activity, but not more before 4 hours. In fact, take it 1 hour before sexual activity for maximum effectiveness.  Also, you should avoid taking the medicine more than once daily. Avoid a high-fat meal before taking this drug.

The dosage prescribed by the doctor will depend your medical condition, medical history and other medicines that you may be taking. You need to inform your doctor about the medicines you are currently taking. Also, it is strongly recommended not to use this drug along with medicines such as riociguat or medicines containing nitrate including recreational drugs known as poppers.

Side Effects of Sildenafil :

Common side effects of this drug include fatigue, dizziness, headache, hot flashes or stomach upset.  This drug can cut blood supply to the optic nerve. As a consequence, you may experience blurred vision, sensitivity to light, color blindness, etc. In rare cases, sildenafil can also lead to complete vision loss.

To lower common side-effects such as dizziness and lightheadedness, it is advised not to hurry when rising from a sitting or lying position.

You need to inform your doctor in advance if you have any heart problem as sexual activity may put extra strain on your heart. Seek immediate medical help if during sex, you experience heart problems and side effects such as extreme dizziness, fainting, nausea, and pain in chest, jaw, arm, etc.

Mediseller  is  a Supplier of SILDENAFIL Tablet & Exporter in USA, UK & Philippines.

Uses, Benefits, and Side Effects of Testosterone

Testosterone Enanthate Injection

What is testosterone?

Testosterone is a hormone produced by male testicles. It is also produced in small quantities in female ovaries and adrenal system. Testosterone helps maintain men's:

Growth

Sex drive

Facial and body hair

Sperm production

Red blood cell production

Muscle strength and mass

Bone density

Muscle mass, etc.

Testosterone levels dip with age

Testosterone levels are at their peak during adolescence and early adulthood leading to intense sexual desires. However, as people get older their testosterone level dips. In fact, it declines about 1 percent a year after age 30 or 40.

It is, however, important for aging men to determine if declining testosterone level is owing to normal or because of a condition known as hypogonadism in which the body is unable to produce normal amounts of testosterone due to a problem with the testicles or with the pituitary gland that controls the testicles. Testosterone gels or injections are normally prescribed by doctors to remedy the situation.

Testosterone side effects

Seek medical help urgently if you are taking testosteroneinjections and start displaying signs of an allergic such as difficulty in breathing, swelling of your face, lips, tongue, or throat. Testosterone injections could also lead to formation of blood clot in lungs. Call emergency if you experience symptoms like chest pain, dizziness, shortness of breath, urge to cough, tightening of throat, fainting, etc.

Excessive use or abuse of testosterone can cause harmful or irreparable effects, such as enlarged breasts, small testicles, hypertension, infertility, addiction, heart attack, stroke, liver disease, kidney disease, bone growth problems and mental effects such as hostility and violence.

Call your doctor immediately if you experience:

•             Chest pain or pressure with pain spreading to your jaw or shoulder;

•             Rapid weight gain;

•             Swelling in your ankles or feet, lips, etc.

•             Persistent cough, wheezing, rapid breathing, coughing up blood;

•             Pain, swelling, warmth, or redness in one or both legs;

•             Nausea or vomiting;

•               Changes in skin color; 

Palbociclib is used to treat Breast Cancer

                                                                  Palbociclib 

Palbociclib is used to treat Breast Cancer

Palbociclib is a chemotherapy drug that is used to treat a certain type of breast cancer. It works by slowing or completely stopping the growth of malignant cells.

How to use Palbociclib Capsule :-

It is of utmost importance that you take this medicine strictly in accordance with the direction given by your physician. Do not hesitate to get your doubts cleared either from your doctor or your pharmacist. 

How to take the medicine?

The medicine needs to be taken continuously for 21 days followed by 7 days break.  It is called one cycle of treatment.  It needs to be swallowed after you have had your food. Never try to dissolve, chew or crush the capsule before taking it. Also, refrain from consuming the capsule if it looks damaged or broken. Avoid taking the medicine if you vomit immediately after taking it. You can take the capsule at the same time next day.

Your physician will decide upon the dosage based on your medical condition, your response to treatment, other medications that you may be taking and laboratory tests among others.

Additionally, your doctor needs to be fully aware of all the prescription, non-prescription or herbal drugs that you are using. Your doctor may decide to discontinue your medication for some time or cut your dose if you get any side effects. Speak to your doctor for additional information.

Things to avoid :-

Refrain from eating grapefruit or drinking grapefruit juice while you are under this medication unless your doctor gives the green signal.  Shunning of grapefruit is advised because it can increase the chance of side effects with this medicine.

Furthermore, your dosage should be exactly as prescribed by the doctor. Never in any circumstance increase or reduce the dosage on your own. This may increase the severity of side effects without any additional benefit.

HIV Treatment: The Basics

Anti-HIV Drugs

Antiretroviral therapy (ART) is the use of Anti-HIV drugs to treat HIV infection. Patients on ART take a combination of HIV medicines known as HIV treatment regimen every day.

ART is recommended for patients who are HIV positive. It can’t cure HIV, but help people live longer and healthier lives. It can also reduce the risk of HIV transmission.

How do Anti HIV drugs work?

HIV destroys the infection-fighting cells of the immune system. Loss of these cells makes it hard for the body to fight off infections and certain HIV-related cancers.

These medicines prevent HIV from multiplying, which reduces the amount of HIV in the body. Less HIV gives the immune system a chance to recover. Even though there is still some HIV left, the immune system is strong enough to fight off infections.

By reducing the amount of HIV, these medicines also reduce the risk of HIV transmission. The main goal of ART is to reduce viral load to an undetectable level. Patients with HIV who maintain an undetectable viral load have no risk of transmitting HIV to their HIV-negative partner.

When to start taking HIV medicines?

Patients should start ART as soon as possible. People with following conditions are recommended to start ART right away: pregnancy, certain HIV-related illnesses and co-infections, AIDS, and early HIV infection.

What medicines are included in an HIV regimen?

There are many medicines available for HIV regimens. These anti-HIV drugs are grouped into seven drug classes according to how they fight HIV. Initial HIV regimen includes 3 HIV medicines from at least 2 different HIV drug classes.

The selection of an HIV regimen depends on several factors, including side effects of anti-HIV drugs and potential drug interactions between medicines. There are several HIV regimens to choose from.

What you should know about taking HIV medicines?

Side effects: Sometimes, these medicines can cause side effects. Most are manageable, but a few can be serious. Overall, the benefits are far outweighing the risk of side effects. Newer regimens cause fewer side effects than regimens used in the past.

Side effects can vary depending on the medicine and the person taking it. Some side effects, like headaches or dizziness, may not be serious. Other such as swelling of the throat and tongue or liver damage, can be life-threatening.

Drug interactions: Anti HIV drugs can interact with other HIV medicines in an HIV regimen. They can interact with other medicines, nutritional supplements, vitamins, and herbal products. A drug interaction reduces or increases a medicine's effect. It can also cause unwanted side effects.

Drug resistance: When HIV multiplies, the virus sometimes mutates and makes variations of it. Variations that develop while a patient is taking HIV medicines can lead to drug-resistant strains of HIV. The medicines that previously controlled a person’s HIV are not effective against the new one, drug-resistant HIV.

Poor adherence to an HIV regime like not taking HIV medicines every day or exactly as prescribed—increases the risk of drug resistance and thus, treatment failure.

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