Side Effects caused by Injectable Fertility Drugs (Gonadotropins)

HMG Injections

What are gonadotropins?

Gonadotropins are fertility inducing drugs. It is administered by injection and contain follicle-stimulating hormone (FSH). The hormone FSH is either injected alone or sometimes along with luteinizing hormone (LH). During a regularly occurring menstrual cycle, the pituitary gland in the brain is responsible for stimulating FSH and LH to produce an egg in ovary. When FSH (alone or with LH) is injected, it stimulates the ovary to make multiple follicles (cysts containing eggs). There are other fertility drugs as well such as clomiphene citrate, which work in tandem with the brain in order to coax the ovaries to produce egg.

How are these medications used?

Gonadotropins are employed by doctors during fertility treatments, generally during intrauterine insemination (IUI) or in vitro fertilization (IVF). Injections of gonadotropins are given in the beginning of the menstrual cycle to encourage production of multiple healthy eggs. Human chorionic gonadotropin (hCG) is then injected to stimulate the ovary to release the egg once it reaches maturity.  During the treatment, doctors monitor the patients closely using ultrasound to prevent side effects and risks.

What are some of the potential side effects of gonadotropins?

Ovarian Hyper stimulation Syndrome (OHSS)

OHSS refers to the condition in which the ovaries become large and fluid accumulates in the abdomen. Around 10% to 20% of patients complain of discomfort but the symptoms usually go away in due course of time. However, more severe complications can occur in approximately 1% of the cases marked by nausea, vomiting, fast weight gain, dehydration, blood clots, kidney dysfunction, twisting of an ovary (torsion), fluid collections in the chest and abdomen, and, in rare conditions even death.

Using injectable gonadotropins enhances the probability of multiple implantations (twins or more), by as much as 30 % which in normal pregnancy occur in 1% to 2% of women. There is 5% chance of triplets as well.  Being pregnant with twins or triplets puts a woman at risk by enhancing the threat of miscarriage, premature delivery, abnormalities in the new born baby, pregnancy-induced hypertension, bleeding, along with other pregnancy related complications.

Use, benefits and side effects of Clenbuterol Tablets

                                                   
                                               

Use, benefits and side effects of Clenbuterol tablets

Clenbuterol is a compound that belongs to a class of drugs called beta2-agonists. The drug is both a decongestant and a bronchodilator. A decongestant dilutes the blood which in turn brings down the blood pressure.  A bronchodilator dilates or widens the bronchial muscles which in turn allows them to carry more oxygen which in turn helps in treating asthma. In the United States, Clenbuterol is not approved by FDA for human administration though in countries in Europe, Asia and Latin America, clenbuterol is approved for treating asthma.

Dosage and administration

As mentioned above, clenbuterol is usually taken to reduce complications arising out of asthma. When used for this purpose, the suggested dosage is between 0.02 and 0.03 milligrams per day. Clenbuterol is both available in tablet as well as inhaler form for asthma treatment. It is recommended that you should not overdose on it and use it as per the dosage suggested by your doctor.

Clenbuterol is not steroid, but it possess some properties similar to anabolic steroids which in turn equips them with the ability to build muscle, lose weight and boost performance.  Clenbuterol when used for this purpose can be acquired as a tablet, liquid, or injection and in quantity ranging from 0.06 to 0.12 milligrams per day.

The takeaway

Clenbuterol isn’t approved by the FDA human administration. A liquid form of the drug is approved to treat airway obstruction in horses. Outside of the United States, it can be used to treat asthma or chronic obstructive pulmonary disease (COPD).

Despite little evidence of its ability to boost performance, Clenbuterol is present on the World Anti-Doping Agency’s (WADA) Prohibited List. Professional athletes testing positive for this drug run the risk of disqualification and getting stripped of their medals.

Side effects of Clenbuterol

•          Rapid fat burning

•          Nervousness

•          Increased heart rate

•          Chest pain, etc

Mediseller is a Supplier and Exporter of Clenbuterol Tablet, Clenbuterol Capsule, Clenbuterol Medicine, in the USA, UK, Philippines From India ..

Uses, Benefits, and Side Effects of Testosterone

Testosterone Enanthate Injection

What is testosterone?

Testosterone is a hormone produced by male testicles. It is also produced in small quantities in female ovaries and adrenal system. Testosterone helps maintain men's:

Growth

Sex drive

Facial and body hair

Sperm production

Red blood cell production

Muscle strength and mass

Bone density

Muscle mass, etc.

Testosterone levels dip with age

Testosterone levels are at their peak during adolescence and early adulthood leading to intense sexual desires. However, as people get older their testosterone level dips. In fact, it declines about 1 percent a year after age 30 or 40.

It is, however, important for aging men to determine if declining testosterone level is owing to normal or because of a condition known as hypogonadism in which the body is unable to produce normal amounts of testosterone due to a problem with the testicles or with the pituitary gland that controls the testicles. Testosterone gels or injections are normally prescribed by doctors to remedy the situation.

Testosterone side effects

Seek medical help urgently if you are taking testosteroneinjections and start displaying signs of an allergic such as difficulty in breathing, swelling of your face, lips, tongue, or throat. Testosterone injections could also lead to formation of blood clot in lungs. Call emergency if you experience symptoms like chest pain, dizziness, shortness of breath, urge to cough, tightening of throat, fainting, etc.

Excessive use or abuse of testosterone can cause harmful or irreparable effects, such as enlarged breasts, small testicles, hypertension, infertility, addiction, heart attack, stroke, liver disease, kidney disease, bone growth problems and mental effects such as hostility and violence.

Call your doctor immediately if you experience:

•             Chest pain or pressure with pain spreading to your jaw or shoulder;

•             Rapid weight gain;

•             Swelling in your ankles or feet, lips, etc.

•             Persistent cough, wheezing, rapid breathing, coughing up blood;

•             Pain, swelling, warmth, or redness in one or both legs;

•             Nausea or vomiting;

•               Changes in skin color; 

Palbociclib is used to treat Breast Cancer

                                                                  Palbociclib 

Palbociclib is used to treat Breast Cancer

Palbociclib is a chemotherapy drug that is used to treat a certain type of breast cancer. It works by slowing or completely stopping the growth of malignant cells.

How to use Palbociclib Capsule :-

It is of utmost importance that you take this medicine strictly in accordance with the direction given by your physician. Do not hesitate to get your doubts cleared either from your doctor or your pharmacist. 

How to take the medicine?

The medicine needs to be taken continuously for 21 days followed by 7 days break.  It is called one cycle of treatment.  It needs to be swallowed after you have had your food. Never try to dissolve, chew or crush the capsule before taking it. Also, refrain from consuming the capsule if it looks damaged or broken. Avoid taking the medicine if you vomit immediately after taking it. You can take the capsule at the same time next day.

Your physician will decide upon the dosage based on your medical condition, your response to treatment, other medications that you may be taking and laboratory tests among others.

Additionally, your doctor needs to be fully aware of all the prescription, non-prescription or herbal drugs that you are using. Your doctor may decide to discontinue your medication for some time or cut your dose if you get any side effects. Speak to your doctor for additional information.

Things to avoid :-

Refrain from eating grapefruit or drinking grapefruit juice while you are under this medication unless your doctor gives the green signal.  Shunning of grapefruit is advised because it can increase the chance of side effects with this medicine.

Furthermore, your dosage should be exactly as prescribed by the doctor. Never in any circumstance increase or reduce the dosage on your own. This may increase the severity of side effects without any additional benefit.

Everything You Need to Know About Anticancer

Symptoms, Classification and Treatment of Cancer

Anti Cancer is a deadly disease caused by the uncontrollable or abnormal growth of cells anywhere in the body.  These abnormal cells are called cancer cells or malignant cells which in turn affect normal body tissues. So far, medical science has detected more than 200 different types and forms of cancer. Primary factors that may induce a cell to grow and divide at a rate not deemed normal could be gene mutation, exposure to toxins, pathogens, and radiation. These unusual cells are named cancer cells malignant cells or tumor cells

Anti Cancer symptoms

Anti Cancer symptoms and signs generally depend upon the type and stage of cancer. General symptoms common to cancer are:

• Fatigue
• Sudden weight loss. In some instances, it could be sudden weight gain as well.
• Change in bowel or bladder function
• Change in size, color, shape, or thickness of a wart or mole
• Persistent bleeding and bruising without any known cause
• Persistent cough, voice change and difficulty breathing
• Lumps under the skin which can be felt from outside
• Changes in tone and texture of the skin.
• Sores that won’t heal for a long time despite treatment could also be an indicator of cancer.
• Although there are quite a few tests or screening procedure to diagnose cancer, the most definitive diagnosis comes from a biopsy of the suspected cancer tissue.

Different types of cancers

1. Carcinoma: cancer that starts in the skin or in tissues that line or spread interior organs such as lung, colon, skin, pancreas, ovary, etc.
2. Sarcoma: Cancer that traces its origin to the bone, cartilage, fat, muscle, blood vessels, etc. 
3. Leukemia: Cancer that begins in the bone marrow and causes large numbers of abnormal blood cells to enter the blood.
4. Central nervous system cancers: Cancers that begin in the brain and spinal cord

What specialists treat cancer?

Doctors gaining practical experience in the treatment of cancer are known as oncologists. Doctors may be surgeon, a radiation therapy expert or a medical oncologist. A surgeon as the name suggests teats cancer through surgery. A radiation therapy expert treats cancer by radiation whereas a medical oncologist administers chemotherapy.  Sometimes a patient may require a combination of surgery and radiation or surgery and chemotherapy. As such different experts may have to collaborate with each other to treat cancer

In addition, the service of other specialists may be required based upon the location of cancer. For example, an immunologist may be called for cancers affecting the immune system. More often than not your primary care physician and main oncologist together decide the line of treatment best suited for you.

Cancer treatment

Line of treatment depends upon the type and stage of cancer along with the body part, it has affected. Cancer is usually treated through radiation, surgery or chemotherapy or the combination of these treatment methods.

Palliative therapy is administered to patients who are terminally ill i.e. their cancer is never again treatable. Palliative therapy is generally reserved for patients for incurable cases and its primary objective is to ease the pain and symptoms of the disease.  Palliative therapy may include medications or treatment through alternate options such as ant nausea medications.

List of Anti Cancer Drugs By Mediseller