Pirfenidone Can Prolong Pulmonary Fibrosis Patients’ Lives

PIRFENEX TABLETS

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Pirfenidone Can Prolong Pulmonary Fibrosis Patients’ Lives:-

Esbriet or Pirfenidone can prolong idiopathic pulmonary fibrosis (IPF) patients’ life, according to a review of clinical trials. Researchers also said that Pirfenidone or Pirfenex tablets are safe but do not help every IPF patient.

Pulmonary fibrosis is the most common interstitial lung disease or a group of disorders that involve scarring of lung tissue. It can lead to a progressive decline in lung function and poor quality of life, and also early death.

The disease’s progression gets worse by comorbidities, or other disorders, which includes pulmonary hypertension and sleep-disordered breathing. Scientists believe it is triggered by damage to protective epithelial cells in the alveoli and the release of cytokines that trigger inflammation. Cytokines promote cell to cell communication in immune responses and stimulate the movement of cells toward sites of inflammation, infection, and injury.

Earlier studies indicated that IPF fails to respond to immunotherapy. Recent trials have demonstrated that novel anti-fibrotic agents have improved lung function over time.

According to the review, Pirfenidone slows IPF patients’ decline in respiratory function and increases their progression-free survival. It also reduces mortality that other anti-fibrotic therapies such as Ofev are unable to do, researchers said.

Based on these findings, the United States Food and Drug Administration (FDA) has approved Pirfenextablets for treating IPF in 2014.

More recently, the ASCEND phase 3 clinical trial supported Pirfenidone’s effectiveness. The study involving 555 patients showed that Pirfenidone improved respiratory function, progression-free survival, and ability to exercise.

An analysis of 2 clinical trials indicated that factors like patient age, smoking status, and geographic origin had no impact on Pirfenidone’s effectiveness.

The trials have also shown that prolonged treatment that is beyond 6 months continued to reduce the risk of IPF patients’ respiratory decline and death. Pooled data from 5 clinical studies covering 1,299 patients supported a previous finding that Pirfenidone is well-tolerated.

Another finding was that a combination of Pirfenidone and amino acid N-acetylcysteine worsened IPF patients’ respiratory function, compared with Pirfenidone alone. The discovery came out of the recent PANORAMA phase 2 trials.

Although the results on Pirfenidone are encouraging, the researchers who did the review said doctors should approach its use with caution. That is because not all IPF patients have better respiratory function and live longer after taking Pirfenex tablets.

Individuals with more rapidly declining lung function prior to the beginning, Pirfenidone treatment is more likely to experience the benefit.

Side Effects:-

Side effects of Pirfenidone include gastrointestinal problems, weight loss, skin reactions, anorexia, and fatigue, according to the review. Patients taking it should avoid smoking and drugs that inhibit Pirfenidone’s metabolism in the liver, the researchers said.

Those taking Pirfenidone should be carefully monitored, particularly those with severe liver or kidney dysfunction.

The benefits of early treatment with Pirfenidone, compared with the risks, have yet to be investigated.

Note: Before initiating treatment, a thorough dialogue with the patient that includes an educational overview of its benefits, risks, and limitations are recommended.

Anti Cancer Medicines

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Cancer Prevention: Some Tips to Reduce Your Risk :-

Cancer is caused by damage to our DNA, if a cell develops too much damage to its DNA it can start to grow and multiply out of control; this is how this disease starts. Some patients having the disease will have only one treatment, but most people have a combination of treatments, such as surgery with chemotherapy, which uses one or more anti cancer medicines and/or radiation therapy.

You might have probably heard conflicting reports about cancer prevention. Sometimes a specific prevention tip recommended in one study is not advised in another. However, it is well accepted that your chances of developing the disease are affected by the lifestyle you choose.

Simple lifestyle changes will make a big difference, so, consider these tips.

Avoid tobacco :- 

Smoking is linked to lung, mouth, throat, larynx, pancreas, bladder, and cervix and Kidney Cancer. Chewing tobacco has been linked to oral cavity and pancreas cancer. Avoiding tobacco or stop using it is an important part of prevention.

Take healthy diet :-

Keep your diet on fruits, vegetables and other food products from plant sources. Eat lighter and leaner by selecting fewer high-calorie foods.

A report concluded that eating large amounts of processed meat can increase the risk of certain types of cancer, so, limit processed meats.

Women who eat a Mediterranean diet with extra-virgin olive oil and mixed nuts have a reduced risk of breast cancer. It focuses mostly on plant-based foods, such as fruits and vegetables, whole grains, legumes, and nuts.

Protect yourself from sun :-

Skin cancer is the most common diseases and one of the most preventable. Avoid midday sun, stay in the shade, cover exposed areas, wear tightly woven loose fitting clothing, which covers as much of your skin as possible. Opt for bright or dark colors these reflect more ultraviolet radiation than pastels or bleached cotton.

Do not skimp on sunscreen; use a broad-spectrum sunscreen with an SPF of at least 30, even on cloudy days and apply generously, and reapply every two hours or more often if you are swimming or perspiring.

Get vaccinated :-

Cancer prevention includes protection from viral infections, so, talk to your doctor about vaccination against:

Hepatitis B can increase the risk of liver cancer, its vaccine is recommended for adults at high risk, such as who are sexually active but not in a mutually monogamous relationship, people with sexually transmitted infections or who use intravenous drugs, and other.

Human papillomavirus (HPV) is a sexually transmitted virus, which can lead to cervical and other genital cancers and also squamous cell cancers of the head and neck. Its vaccine is recommended for girls and boys ages 11 and 12.

Conclusion :-

Healthy lifestyle is not a guarantee against the disease. But it heaps the odds in favor, by reducing the risk of developing the disease. There are many anti cancer medicines available to treat the disease and at Mediseller you can find the best and certified medicines.